論文 - 詳細
| RRC ID | 19207 |
|---|---|
| 著者 | Usami S, Motoyama S, Koyota S, Wang J, Hayashi-Shibuya K, Maruyama K, Takahashi N, Saito H, Minamiya Y, Takasawa S, Ogawa J, Sugiyama T. |
| タイトル | Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Regenerating gene (REG) I plays important roles in cancer cell biology. The purpose of this study was to determine whether REG I affects cytokine production in cancer cells. We transfected TE-5 and TE-9 squamous esophageal cancer cells with REG Ialpha and Ibeta and examined its effects on cytokine expression. We found that transfecting TE-5 and TE-9 cells with REG I Ialpha and Ibeta led to significantly increased expression of interleukin (IL)-6 mRNA and protein, but it had little or no effect on expression of IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL-17A, interferon-gamma, tumor necrosis factor-alpha, granulocyte-colony stimulating factor or transforming growth factor-beta1. The elevated IL-6 expression seen in REG Ialpha transfectants was silenced by small interfering RNA-mediated knockdown. These finding suggest that REG I may act through IL-6 to exert effects on squamous esophageal cancer cell biology. |
| 巻・号 | 392(1) |
| ページ | 4-8 |
| 公開日 | 2010-1-29 |
| DOI | 10.1016/j.bbrc.2009.12.129 |
| PII | S0006-291X(09)02515-7 |
| PMID | 20056108 |
| MeSH | Cell Line, Tumor Esophageal Neoplasms / metabolism* Humans Interleukin-6 / biosynthesis* Lithostathine / genetics Lithostathine / metabolism* Neoplasms, Squamous Cell / metabolism* Transfection |
| IF | 2.985 |
| 引用数 | 9 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | TE-5 (RCB1949) TE-9 (RCB1988) |