RRC ID 19267
Author Garrison JL, Macosko EZ, Bernstein S, Pokala N, Albrecht DR, Bargmann CI.
Title Oxytocin/vasopressin-related peptides have an ancient role in reproductive behavior.
Journal Science
Abstract Many biological functions are conserved, but the extent to which conservation applies to integrative behaviors is unknown. Vasopressin and oxytocin neuropeptides are strongly implicated in mammalian reproductive and social behaviors, yet rodent loss-of-function mutants have relatively subtle behavioral defects. Here we identify an oxytocin/vasopressin-like signaling system in Caenorhabditis elegans, consisting of a peptide and two receptors that are expressed in sexually dimorphic patterns. Males lacking the peptide or its receptors perform poorly in reproductive behaviors, including mate search, mate recognition, and mating, but other sensorimotor behaviors are intact. Quantitative analysis indicates that mating motor patterns are fragmented and inefficient in mutants, suggesting that oxytocin/vasopressin peptides increase the coherence of mating behaviors. These results indicate that conserved molecules coordinate diverse behavioral motifs in reproductive behavior.
Volume 338(6106)
Pages 540-3
Published 2012-10-26
DOI 10.1126/science.1226201
PII 338/6106/540
PMID 23112335
PMC PMC3597094
MeSH Amino Acid Sequence Animals Biological Evolution* CHO Cells Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / agonists Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / pharmacology Caenorhabditis elegans Proteins / physiology* Cricetinae Humans Male Neuropeptides / chemistry Neuropeptides / genetics Neuropeptides / pharmacology Neuropeptides / physiology* Oxytocin / chemistry Oxytocin / genetics Oxytocin / pharmacology Oxytocin / physiology* Receptors, G-Protein-Coupled / agonists Receptors, G-Protein-Coupled / genetics Receptors, G-Protein-Coupled / physiology* Reproduction Sexual Behavior, Animal / physiology* Vasopressins / chemistry Vasopressins / genetics Vasopressins / pharmacology Vasopressins / physiology*
IF 41.058
Times Cited 83
WOS Category NEUROSCIENCES
Resource
C.elegans F39C12.4 (tm2385) T07D10.2 (tm2765) F14F4.1 (tm2243) tm2385