RRC ID 19281
Author Tokiwano T, Satoh H, Obara T, Hirota H, Yoshizawa Y, Yamamoto Y.
Title A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta.
Journal Biosci Biotechnol Biochem
Abstract The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC(50)=21 microM) which is greater than that of leucotylic acid (2) and the structurally related anti-tumor agent, betulinic acid (4).
Volume 73(11)
Pages 2525-7
Published 2009-11-1
DOI 10.1271/bbb.90419
PII JST.JSTAGE/bbb/90419
PMID 19897905
MeSH Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology* Ascomycota / chemistry* Cell Proliferation / drug effects HL-60 Cells Humans Leukemia / pathology* Lichens / chemistry* Triterpenes / chemistry Triterpenes / isolation & purification* Triterpenes / pharmacology*
IF 1.297
Times Cited 9
WOS Category FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Human and Animal Cells HL60 (RCB0041)