論文 - 詳細
| RRC ID | 19281 |
|---|---|
| 著者 | Tokiwano T, Satoh H, Obara T, Hirota H, Yoshizawa Y, Yamamoto Y. |
| タイトル | A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC(50)=21 microM) which is greater than that of leucotylic acid (2) and the structurally related anti-tumor agent, betulinic acid (4). |
| 巻・号 | 73(11) |
| ページ | 2525-7 |
| 公開日 | 2009-11-1 |
| DOI | 10.1271/bbb.90419 |
| PII | JST.JSTAGE/bbb/90419 |
| PMID | 19897905 |
| MeSH | Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology* Ascomycota / chemistry* Cell Proliferation / drug effects HL-60 Cells Humans Leukemia / pathology* Lichens / chemistry* Triterpenes / chemistry Triterpenes / isolation & purification* Triterpenes / pharmacology* |
| IF | 1.516 |
| 引用数 | 9 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |