Reference - Detail
|Author||Tokiwano T, Satoh H, Obara T, Hirota H, Yoshizawa Y, Yamamoto Y.|
|Title||A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta.|
|Journal||Biosci Biotechnol Biochem|
The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC(50)=21 microM) which is greater than that of leucotylic acid (2) and the structurally related anti-tumor agent, betulinic acid (4).
|MeSH||Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology* Ascomycota / chemistry* Cell Proliferation / drug effects HL-60 Cells Humans Leukemia / pathology* Lichens / chemistry* Triterpenes / chemistry Triterpenes / isolation & purification* Triterpenes / pharmacology*|
|WOS Category||FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY|
|Human and Animal Cells||HL60 (RCB0041)|