論文 - 詳細
| RRC ID | 19302 |
|---|---|
| 著者 | Khuda II, Koide N, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. |
| タイトル | Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. |
| ジャーナル | Immunology |
| Abstract |
Astrocyte elevated gene-1 (AEG-1) is induced by human immunodeficiency virus 1 (HIV-1) infection and involved in tumour progression, migration and invasion as a nuclear factor-kappaB (NF-kappaB) -dependent gene. The involvement of AEG-1 on lipopolysaccharide (LPS) -induced proinflammatory cytokine production was examined. AEG-1 was induced via NF-kappaB activation in LPS-stimulated U937 human promonocytic cells. AEG-1 induced by LPS subsequently regulated NF-kappaB activation. The prevention of AEG-1 expression inhibited LPS-induced tumour necrosis factor-alpha and prostaglandin E(2) production. The AEG-1 activation was not induced by toll-like receptor ligands other than LPS. Therefore, AEG-1 was suggested to be a LPS-responsive gene and involved in LPS-induced inflammatory response. |
| 巻・号 | 128(1 Suppl) |
| ページ | e700-6 |
| 公開日 | 2009-9-1 |
| DOI | 10.1111/j.1365-2567.2009.03063.x |
| PII | IMM3063 |
| PMID | 19740331 |
| PMC | PMC2753960 |
| MeSH | Cell Adhesion Molecules / biosynthesis* Cell Adhesion Molecules / genetics Cell Line, Tumor Dinoprostone / biosynthesis Dinoprostone / immunology Humans Lipopolysaccharides / immunology* Membrane Proteins Monocytes / drug effects Monocytes / immunology* NF-kappa B / agonists NF-kappa B / metabolism RNA-Binding Proteins Signal Transduction Toll-Like Receptor 4 / metabolism* Tumor Necrosis Factor-alpha / biosynthesis |
| IF | 5.016 |
| 引用数 | 38 |
| WOS 分野 | IMMUNOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | U-937 DE-4(RCB0435) |