論文 - 詳細
| RRC ID | 19316 |
|---|---|
| 著者 | Morioka K, Tanikawa C, Ochi K, Daigo Y, Katagiri T, Kawano H, Kawaguchi H, Myoui A, Yoshikawa H, Naka N, Araki N, Kudawara I, Ieguchi M, Nakamura K, Nakamura Y, Matsuda K. |
| タイトル | Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. |
| ジャーナル | Cancer Sci |
| Abstract |
Osteosarcoma is the most prevalent bone malignant tumor in children and adolescents, and displays heterogeneous histology and high propensity for distant metastasis. Although adjuvant chemotherapy remarkably improved treatment outcome over the past few decades, prognosis for osteosarcoma patients with pulmonary metastasis is still unsatisfactory. To identify novel therapeutic targets for osteosarcoma, we investigated the gene expression profile of osteosarcomas by cDNA microarray analysis and found transactivation of receptor tyrosine kinase-like orphan receptor 2 (ROR2) expression in the majority of osteosarcoma samples. Treatment of osteosarcoma cell lines with siRNA against ROR2 significantly inhibited cell proliferation and migration. We also identified wingless-type MMTV integration site family, member 5B (WNT5B) as a putative ROR2 ligand and that the physiological interaction of WNT5B and ROR2 could enhance cell migration, indicating the possible roles of ROR2 and WNT5B in the metastatic property of osteosarcoma cells. Taken together, our findings revealed that the WNT5B/ROR2 signaling pathway is a promising therapeutic target for osteosarcoma. |
| 巻・号 | 100(7) |
| ページ | 1227-33 |
| 公開日 | 2009-7-1 |
| DOI | 10.1111/j.1349-7006.2009.01165.x |
| PII | CAS1165 |
| PMID | 19486338 |
| MeSH | Animals Bone Neoplasms / drug therapy Bone Neoplasms / enzymology* COS Cells Cell Line Cell Line, Tumor Chlorocebus aethiops Humans Mice NIH 3T3 Cells Osteosarcoma / drug therapy Osteosarcoma / enzymology* Receptor Protein-Tyrosine Kinases / antagonists & inhibitors Receptor Protein-Tyrosine Kinases / genetics Receptor Protein-Tyrosine Kinases / metabolism* Receptor Tyrosine Kinase-like Orphan Receptors Receptors, Cell Surface / antagonists & inhibitors Receptors, Cell Surface / genetics Receptors, Cell Surface / metabolism* Signal Transduction Wnt Proteins / genetics Wnt Proteins / metabolism |
| IF | 4.966 |
| 引用数 | 54 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NOS-1(RCB1032) 143B/TK^(-)neo^(R)(RCB0701) |