Reference - Detail
| RRC ID | 19379 |
|---|---|
| Author | Matsuzawa T, Hara F, Tohda H, Uemura H, Takegawa K. |
| Title | Promotion of glycerol utilization using ethanol and 1-propanol in Schizosaccharomyces pombe. |
| Journal | Appl Microbiol Biotechnol |
| Abstract |
The fission yeast Schizosaccharomyces pombe does not grow in media containing glycerol as a sole carbon source but uses glycerol in the presence of ethanol. Ethanol, but not glycerol, triggered upregulation of gld1+ and fbp1+ during glucose starvation even though gld1+ and fbp1+ are essential for growth on glycerol. This upregulation occurred at a very low concentration of ethanol. The transcriptional regulation of gld1+ was tested in the presence of various alcohols, and both ethanol and 1-propanol were found to induce gld1+ and to support growth in glycerol-containing media. We suggest that S. pombe has a novel ethanol and/or 1-propanol recognition mechanism that upregulates glycerol utilization during glucose starvation. |
| Volume | 95(2) |
| Pages | 441-9 |
| Published | 2012-7-1 |
| DOI | 10.1007/s00253-012-3971-x |
| PMID | 22370953 |
| MeSH | 1-Propanol / metabolism* Carbon / metabolism Culture Media / chemistry Ethanol / metabolism* Fructose-Bisphosphatase / biosynthesis Gene Expression Gene Expression Regulation, Fungal* Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) / biosynthesis Glycerol / metabolism* Schizosaccharomyces / genetics Schizosaccharomyces / growth & development Schizosaccharomyces / metabolism* Transcription, Genetic Up-Regulation |
| IF | 3.53 |
| Times Cited | 3 |
| WOS Category | BIOTECHNOLOGY & APPLIED MICROBIOLOGY |
| Resource | |
| Yeast | FY18624 FY18625 FY7512 |