論文 - 詳細
| RRC ID | 19384 |
|---|---|
| 著者 | Oura R, Arakaki R, Yamada A, Kudo Y, Tanaka E, Hayashi Y, Ishimaru N. |
| タイトル | Induction of rapid T cell death and phagocytic activity by Fas-deficient lpr macrophages. |
| ジャーナル | J Immunol |
| Abstract |
Peripheral T cells are maintained by the apoptosis of activated T cells through the Fas-Fas ligand system. Although it is well known that normal T cells fail to survive in the Fas-deficient immune condition, the molecular mechanism for the phenomenon has yet to be elucidated. In this study, we demonstrate that rapid cell death and clearance of normal T cells were induced by Fas-deficient lpr macrophages. Transfer of normal T cells into lpr mice revealed that Fas expression on donor T cells was promptly enhanced through the IFN-γ/IFN-γR. In addition, Fas ligand expression and phagocytic activity of lpr macrophages were promoted through increased NF-κB activation. Controlling Fas expression on macrophages plays an essential role in maintaining T cell homeostasis in the peripheral immune system. Our data suggest a critical implication to the therapeutic strategies such as transplantation and immunotherapy for immune disorder or autoimmunity related to abnormal Fas expression. |
| 巻・号 | 190(2) |
| ページ | 578-85 |
| 公開日 | 2013-1-15 |
| DOI | 10.4049/jimmunol.1103794 |
| PII | jimmunol.1103794 |
| PMID | 23255359 |
| PMC | PMC3539689 |
| MeSH | Animals Cell Death / immunology Cell Movement / genetics Cell Movement / immunology Fas Ligand Protein / genetics Fas Ligand Protein / immunology Gene Expression Regulation Immunomodulation / genetics Macrophages / immunology* Macrophages / metabolism* Mice Mice, Inbred MRL lpr Mice, Transgenic NF-kappa B / metabolism Phagocytosis / immunology* T-Lymphocytes / immunology* T-Lymphocytes / metabolism* fas Receptor / deficiency* |
| IF | 4.886 |
| 引用数 | 5 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 実験動物マウス | RBRC00267 |