Reference - Detail
| RRC ID | 19649 |
|---|---|
| Author | Konishi H, Kikuchi S, Ochiai T, Ikoma H, Kubota T, Ichikawa D, Fujiwara H, Okamoto K, Sakakura C, Sonoyama T, Kokuba Y, Sasaki H, Matsui T, Otsuji E. |
| Title | Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice. |
| Journal | Anticancer Res |
| Abstract |
Peritoneal dissemination of gastric cancer is a refractory disease. This paper focuses on the efficacy of actin-binding marine macrolide latrunculin A, which quickly inhibits actin polymerization and disrupts the function of the actin cytoskeleton. The effects of latrunculin A on cell viability in vitro were evaluated by treatment of MKN45 or NUGC-4 cell cultures. An in vitro viability assay demonstrated an anticancer effect of latrunculin A in a dose-dependent manner. Latrunculin A induced acute cell injury and programmed cell death through activating the caspase-3/7 pathway. In vivo, MKN45 or NUGC-4 cells were intraperitoneally inoculated into nude mice, as a model of peritoneal dissemination. Intraperitoneal (i.p.) injection of latrunculin A significantly improved survival rate in mice without any major side-effects. Data indicated that latrunculin A has strong anticancer effects, and it may be a new candidate i.p. drug against peritoneal dissemination of gastric cancer in humans. |
| Volume | 29(6) |
| Pages | 2091-7 |
| Published | 2009-6-1 |
| PII | 29/6/2091 |
| PMID | 19528469 |
| MeSH | Adenocarcinoma / drug therapy Adenocarcinoma / secondary Animals Apoptosis / drug effects Bridged Bicyclo Compounds, Heterocyclic / pharmacology* Carcinoma, Signet Ring Cell / drug therapy Carcinoma, Signet Ring Cell / secondary Caspases / metabolism Cell Line, Tumor Humans Injections, Intraperitoneal Male Marine Toxins / pharmacology* Mice Mice, Inbred BALB C Mice, Nude Peritoneal Neoplasms / drug therapy* Peritoneal Neoplasms / secondary* Stomach Neoplasms / drug therapy* Stomach Neoplasms / pathology Thiazolidines / pharmacology* Xenograft Model Antitumor Assays |
| IF | 1.994 |
| Times Cited | 31 |
| WOS Category | ONCOLOGY |
| Resource | |
| Human and Animal Cells | NUGC-4(RCB1939) |