Reference - Detail
| RRC ID | 19654 |
|---|---|
| Author | Kayashima Y, Yamakawa-Kobayashi K. |
| Title | Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance. |
| Journal | Biomed Res |
| Abstract |
Peroxiredoxins (Prxs) are a family of multifunctional antioxidant thioredoxin-dependent peroxidases. We used Drosophila melanogaster to examine the function of Prx3, the Drosophila homolog of human PRDX3. The oxidative stress response in adult Drosophila is age-dependent. RNAiinduced Prx3 knockdown in adult flies did not change their phenotype in normal conditions, but they had a shorter survival than the Prx3(+) controls in the presence of H2O2. The expression levels of the Prx3 were reduced by aging. These results suggest that Prx3 plays an important role in the oxidative stress response and is involved in the age-dependent competence of the oxidative stress response. |
| Volume | 33(5) |
| Pages | 319-22 |
| Published | 2012-11-1 |
| DOI | 10.2220/biomedres.33.319 |
| PII | DN/JST.JSTAGE/biomedres/33.319 |
| PMID | 23124252 |
| MeSH | Aging / drug effects Aging / physiology* Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster Gene Knockdown Techniques Humans Hydrogen Peroxide / pharmacology Oxidants / pharmacology Oxidative Stress / drug effects Oxidative Stress / physiology* Peroxidases / genetics Peroxidases / metabolism* Peroxiredoxin III / genetics Peroxiredoxin III / metabolism* |
| IF | 1.429 |
| Times Cited | 2 |
| WOS Category | MEDICINE, RESEARCH & EXPERIMENTAL |
| Resource | |
| Drosophila | 5826R-1 5826R-2 |