論文 - 詳細
| RRC ID | 19698 |
|---|---|
| 著者 | Sanei M, Pickering R, Kumke K, Nasuda S, Houben A. |
| タイトル | Loss of centromeric histone H3 (CENH3) from centromeres precedes uniparental chromosome elimination in interspecific barley hybrids. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Uniparental chromosome elimination occurs in several interspecific hybrids of plants. We studied the mechanism underlying selective elimination of the paternal chromosomes during the early development of Hordeum vulgare × Hordeum bulbosum embryos. The following conclusions regarding the role of the centromere-specific histone H3 variant (CENH3) in the process of chromosome elimination were drawn: (i) centromere inactivity of H. bulbosum chromosomes triggers the mitosis-dependent process of uniparental chromosome elimination in unstable H. vulgare × H. bulbosum hybrids; (ii) centromeric loss of CENH3 protein rather than uniparental silencing of CENH3 genes causes centromere inactivity; (iii) in stable species combinations, cross-species incorporation of CENH3 occurs despite centromere-sequence differences, and not all CENH3 variants get incorporated into centromeres if multiple CENH3s are present in species combinations; and (iv) diploid barley species encode two CENH3 variants, the proteins of which are intermingled within centromeres throughout mitosis and meiosis. |
| 巻・号 | 108(33) |
| ページ | E498-505 |
| 公開日 | 2011-8-16 |
| DOI | 10.1073/pnas.1103190108 |
| PII | 1103190108 |
| PMID | 21746892 |
| PMC | PMC3158150 |
| MeSH | Centromere / chemistry* Chimera Chromosomes, Plant* Histones / metabolism* Hordeum / genetics* Meiosis Mitosis Molecular Sequence Data Plant Proteins / metabolism Uniparental Disomy |
| IF | 9.412 |
| 引用数 | 139 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| コムギ | |