論文 - 詳細
| RRC ID | 19819 |
|---|---|
| 著者 | Imamura N, Motoike I, Shimada N, Nishikori M, Morisaki H, Fukami H. |
| タイトル | An efficient screening approach for anti-Microcystis compounds based on knowledge of aquatic microbial ecosystem. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
To improve the efficiency of screening for anti-Microcystis compounds, we planned to use algae-lysing bacteria that kill the organisms of water blooms. A two step-screening process was carried out, i.e., the screening of algae-lysing bacteria and the selection of anti-Microcystis producers from the bacteria. Sources for the isolation of the bacteria were a co-cultivated fluid of a water sample with axenic Microcystis viridis, a water sample collected in a water bloom season, and a water bloom sample. The water bloom sample was the best source for the isolation of the algae-lysing bacteria and such bacteria were shown to exhibit potent activity. Seventeen strains out of 20 isolated algae-lysing bacteria produced anti-Microcystis activities, and one of the principles was the previously reported argimicin A. These results indicate that algae-lysing bacteria in water blooms may be good sources for potent and selective anticyanobacterial compounds. |
| 巻・号 | 54(7) |
| ページ | 582-7 |
| 公開日 | 2001-7-1 |
| DOI | 10.7164/antibiotics.54.582 |
| PMID | 11560377 |
| MeSH | Cell Extracts / pharmacology DNA, Bacterial / analysis Drug Evaluation, Preclinical / methods* Eukaryota / microbiology* Microcystis / drug effects Pest Control, Biological / methods Phylogeny Pseudomonas putida / chemistry Pseudomonas putida / classification* Pseudomonas putida / genetics RNA, Ribosomal, 16S / classification Water Microbiology* |
| IF | 2.668 |
| 引用数 | 15 |
| WOS 分野 | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 藻類 | NIES-228 NIES-102 |