| RRC ID |
19819
|
| 著者 |
Imamura N, Motoike I, Shimada N, Nishikori M, Morisaki H, Fukami H.
|
| タイトル |
An efficient screening approach for anti-Microcystis compounds based on knowledge of aquatic microbial ecosystem.
|
| ジャーナル |
J Antibiot (Tokyo)
|
| Abstract |
To improve the efficiency of screening for anti-Microcystis compounds, we planned to use algae-lysing bacteria that kill the organisms of water blooms. A two step-screening process was carried out, i.e., the screening of algae-lysing bacteria and the selection of anti-Microcystis producers from the bacteria. Sources for the isolation of the bacteria were a co-cultivated fluid of a water sample with axenic Microcystis viridis, a water sample collected in a water bloom season, and a water bloom sample. The water bloom sample was the best source for the isolation of the algae-lysing bacteria and such bacteria were shown to exhibit potent activity. Seventeen strains out of 20 isolated algae-lysing bacteria produced anti-Microcystis activities, and one of the principles was the previously reported argimicin A. These results indicate that algae-lysing bacteria in water blooms may be good sources for potent and selective anticyanobacterial compounds.
|
| 巻・号 |
54(7)
|
| ページ |
582-7
|
| 公開日 |
2001-7-1
|
| DOI |
10.7164/antibiotics.54.582
|
| PMID |
11560377
|
| MeSH |
Cell Extracts / pharmacology
DNA, Bacterial / analysis
Drug Evaluation, Preclinical / methods*
Eukaryota / microbiology*
Microcystis / drug effects
Pest Control, Biological / methods
Phylogeny
Pseudomonas putida / chemistry
Pseudomonas putida / classification*
Pseudomonas putida / genetics
RNA, Ribosomal, 16S / classification
Water Microbiology*
|
| IF |
2.668
|
| 引用数 |
15
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
IMMUNOLOGY
MICROBIOLOGY
|
| リソース情報 |
| 藻類 |
NIES-228
NIES-102 |
