Reference - Detail
| RRC ID | 19955 |
|---|---|
| Author | Murakami M, Suzuki S, Itou Y, Kodani S, Ishida K. |
| Title | New anabaenopeptins, potent carboxypeptidase-A inhibitors from the cyanobacterium Aphanizomenon flos-aquae. |
| Journal | J Nat Prod |
| Abstract |
Anabaenopeptins I (1) and J (2), two new ureido bond-containing cyclic peptides, were isolated from the cultured cyanobacterium Aphanizomenon flos-aquae (NIES-81) as potent carboxypeptidase-A (CPA) inhibitors. The gross structures of 1 and 2 were established by spectroscopic analysis, including the 2D NMR techniques. The absolute configurations of 1 and 2 were determined by spectral and chemical methods. Anabaenopeptins I and J inhibited CPA with IC(50) values of 5.2 and 7.6 ng/mL, respectively. |
| Volume | 63(9) |
| Pages | 1280-2 |
| Published | 2000-9-1 |
| DOI | 10.1021/np000120k |
| PII | np000120k |
| PMID | 11000037 |
| MeSH | Carboxypeptidases / antagonists & inhibitors* Carboxypeptidases A Cyanobacteria / chemistry* Enzyme Inhibitors / chemistry Enzyme Inhibitors / isolation & purification* Enzyme Inhibitors / pharmacology Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification* Peptides, Cyclic / pharmacology Protein Conformation Spectrum Analysis |
| IF | 3.782 |
| Times Cited | 52 |
| WOS Category | CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY PLANT SCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Algae | NIES-81 |