論文 - 詳細
| RRC ID | 1996 |
|---|---|
| 著者 | Nikawa H, Egusa H, Makihira S, Okamoto T, Kurihara H, Shiba H, Amano H, Murayama T, Yatani H, Hamada T. |
| タイトル | An in vitro evaluation of the adhesion of Candida species to oral and lung tissue cells. |
| ジャーナル | Mycoses |
| Abstract |
The analysis of the adherence capacity of fungi to surfaces of both oral tissue and different tissues would be of interest in the fungal dissemination as an oral and systemic pathogen. We developed an in vitro adenosine triphosphate (ATP)-based assay technique to extract the cellular and fungal ATP separately, which allowed the quantitative evaluation of the adhesion of the yeast to monolayers of human gingival epithelial cells (GEC), gingival fibroblasts (GF) and pulmonary fibroblasts (PF). Seven oral isolates of Candida species (three of Candida albicans, three of Candida tropicalis and one of Candida glabrata) were used in the study. The adherent level of the Candida species varied depending on both the isolates and the cell origins, although all the Candida isolates had a significantly higher level of adherence to GEC than to GF except the single isolate of C. tropicalis. Whereas the adherent level of the five isolates to GEC was significantly higher than that to PF, the adherent level of the remaining two isolates of C. tropicalis to GEC was significantly lower than that to PF. These results suggest that candidal adherence to host tissue cells should be regulated in an isolate-dependent and cell-origin-dependent manner, and that the phenomena may be involved in the colonisation and/or dissemination of the fungi. |
| 巻・号 | 49(1) |
| ページ | 14-7 |
| 公開日 | 2006-1-1 |
| DOI | 10.1111/j.1439-0507.2005.01176.x |
| PII | MYC1176 |
| PMID | 16367812 |
| MeSH | Candida / physiology* Cell Adhesion Cells, Cultured Epithelial Cells / microbiology Fibroblasts / microbiology Gingiva / microbiology Humans Lung / microbiology Species Specificity |
| IF | 3.575 |
| 引用数 | 15 |
| WOS 分野 | DERMATOLOGY MYCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MRC-5(RCB0211) |