RRC ID 1997
Author Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae SC, Tokuhiro S, Chang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kaufman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K.
Title A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.
Journal Nat Genet
Abstract Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-kappaB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.
Volume 37(5)
Pages 478-85
Published 2005-5-1
DOI 10.1038/ng1540
PII ng1540
PMID 15838509
PMC PMC1362949
MeSH Arthritis, Rheumatoid / genetics* Arthritis, Rheumatoid / immunology Arthritis, Rheumatoid / metabolism Autoimmunity / genetics* Autoimmunity / immunology Autoimmunity / physiology Case-Control Studies Chromosomes, Human, Pair 1 Gene Expression Regulation / physiology HLA-DR Antigens / genetics HLA-DR Antigens / immunology HLA-DRB1 Chains Humans Linkage Disequilibrium Molecular Sequence Data Multigene Family Mutation Polymorphism, Single Nucleotide Receptors, Immunologic / genetics* Receptors, Immunologic / metabolism
IF 27.605
Times Cited 271
WOS Category GENETICS & HEREDITY
Resource
Human and Animal Cells RAJI(RCB1647)