論文 - 詳細
RRC ID | 1997 |
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著者 | Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae SC, Tokuhiro S, Chang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kaufman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K. |
タイトル | A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. |
ジャーナル | Nat Genet |
Abstract |
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-kappaB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity. |
巻・号 | 37(5) |
ページ | 478-85 |
公開日 | 2005-5-1 |
DOI | 10.1038/ng1540 |
PII | ng1540 |
PMID | 15838509 |
PMC | PMC1362949 |
MeSH | Arthritis, Rheumatoid / genetics* Arthritis, Rheumatoid / immunology Arthritis, Rheumatoid / metabolism Autoimmunity / genetics* Autoimmunity / immunology Autoimmunity / physiology Case-Control Studies Chromosomes, Human, Pair 1 Gene Expression Regulation / physiology HLA-DR Antigens / genetics HLA-DR Antigens / immunology HLA-DRB1 Chains Humans Linkage Disequilibrium Molecular Sequence Data Multigene Family Mutation Polymorphism, Single Nucleotide Receptors, Immunologic / genetics* Receptors, Immunologic / metabolism |
IF | 27.605 |
引用数 | 271 |
WOS 分野 | GENETICS & HEREDITY |
リソース情報 | |
ヒト・動物細胞 | RAJI(RCB1647) |