Reference - Detail
| RRC ID | 20090 |
|---|---|
| Author | Sano T, Usui T, Ueda K, Osada H, Kaya K. |
| Title | Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp. |
| Journal | J Nat Prod |
| Abstract |
Two new protein phosphatase inhibitors, oscillamide B (1) and C (2), were isolated from the cyanobacteria Planktothrix (Oscillatoria) agardhii and P. rubescens. The structures of the inhibitors were elucidated by analysis of HRFABMS, 1D and 2D NMR spectra, and chemical degradation. These inhibitors are ureido-containing cyclic peptides and inhibited serine/threonine protein phosphatases PP1 and PP2A. The inhibitory activities were closely related to the Arg and N-Me-Hty residues in the peptides. |
| Volume | 64(8) |
| Pages | 1052-5 |
| Published | 2001-8-1 |
| DOI | 10.1021/np0005356 |
| PII | np0005356 |
| PMID | 11520225 |
| MeSH | Chromatography, High Pressure Liquid Cyanobacteria / chemistry* Enzyme Inhibitors / chemistry Enzyme Inhibitors / isolation & purification* Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification* Phosphoprotein Phosphatases / antagonists & inhibitors* Phosphoprotein Phosphatases / metabolism Phosphorylation Substrate Specificity |
| IF | 3.782 |
| Times Cited | 61 |
| WOS Category | CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY PLANT SCIENCES |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Algae | NIES-928 NIES-905 |