| RRC ID |
20090
|
| Author |
Sano T, Usui T, Ueda K, Osada H, Kaya K.
|
| Title |
Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp.
|
| Journal |
J Nat Prod
|
| Abstract |
Two new protein phosphatase inhibitors, oscillamide B (1) and C (2), were isolated from the cyanobacteria Planktothrix (Oscillatoria) agardhii and P. rubescens. The structures of the inhibitors were elucidated by analysis of HRFABMS, 1D and 2D NMR spectra, and chemical degradation. These inhibitors are ureido-containing cyclic peptides and inhibited serine/threonine protein phosphatases PP1 and PP2A. The inhibitory activities were closely related to the Arg and N-Me-Hty residues in the peptides.
|
| Volume |
64(8)
|
| Pages |
1052-5
|
| Published |
2001-8-1
|
| DOI |
10.1021/np0005356
|
| PII |
np0005356
|
| PMID |
11520225
|
| MeSH |
Chromatography, High Pressure Liquid
Cyanobacteria / chemistry*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Phosphoprotein Phosphatases / antagonists & inhibitors*
Phosphoprotein Phosphatases / metabolism
Phosphorylation
Substrate Specificity
|
| IF |
3.782
|
| Times Cited |
61
|
|
WOS Category
|
CHEMISTRY, MEDICINAL
PHARMACOLOGY & PHARMACY
PLANT SCIENCES
|
| Resource |
| Algae |
NIES-928
NIES-905 |
