| RRC ID |
2012
|
| Author |
Numazawa S, Shindo S, Maruyama K, Chibana F, Kawahara Y, Ashino T, Tanaka S, Yoshida T.
|
| Title |
Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital.
|
| Journal |
FEBS Lett
|
| Abstract |
Phenobarbital (PB) induction of CYP2B, a representative target gene of constitutive androstane receptor (CAR), has been observed to be attenuated in preneoplastic lesions of rat liver; however, molecular basis for this attenuation is poorly understood. In this report, we provide evidence indicating that the CAR expressed in the hepatic preneoplastic lesions of rats and mice was resistant to nuclear translocation and transactivation of the PB-responsive enhancer module upon PB treatment. These observations suggest that the attenuation of the induction of CYP2B by PB in hepatic preneoplastic lesions is evidently a consequence of impaired nuclear translocation of CAR.
|
| Volume |
579(17)
|
| Pages |
3560-4
|
| Published |
2005-7-4
|
| DOI |
10.1016/j.febslet.2005.05.028
|
| PII |
S0014-5793(05)00636-8
|
| PMID |
15953603
|
| MeSH |
Active Transport, Cell Nucleus / drug effects
Animals
Cell Nucleus / chemistry
Cell Nucleus / metabolism*
Constitutive Androstane Receptor
Cytochrome P-450 CYP2B1 / genetics
Cytochrome P-450 CYP2B1 / metabolism*
Down-Regulation
Liver / drug effects*
Liver / pathology
Liver Neoplasms / metabolism*
Male
Mice
Phenobarbital / pharmacology*
Precancerous Conditions / metabolism*
Rats
Receptors, Cytoplasmic and Nuclear / analysis
Receptors, Cytoplasmic and Nuclear / genetics
Receptors, Cytoplasmic and Nuclear / metabolism*
Transcription Factors / analysis
Transcription Factors / genetics
Transcription Factors / metabolism*
Transcriptional Activation / drug effects
|
| IF |
3.057
|
| Times Cited |
9
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| DNA material |
P450 2B1 (CYP2B1) cDNA (RDB01245) |
