Reference - Detail
| RRC ID | 2012 |
|---|---|
| Author | Numazawa S, Shindo S, Maruyama K, Chibana F, Kawahara Y, Ashino T, Tanaka S, Yoshida T. |
| Title | Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital. |
| Journal | FEBS Lett |
| Abstract |
Phenobarbital (PB) induction of CYP2B, a representative target gene of constitutive androstane receptor (CAR), has been observed to be attenuated in preneoplastic lesions of rat liver; however, molecular basis for this attenuation is poorly understood. In this report, we provide evidence indicating that the CAR expressed in the hepatic preneoplastic lesions of rats and mice was resistant to nuclear translocation and transactivation of the PB-responsive enhancer module upon PB treatment. These observations suggest that the attenuation of the induction of CYP2B by PB in hepatic preneoplastic lesions is evidently a consequence of impaired nuclear translocation of CAR. |
| Volume | 579(17) |
| Pages | 3560-4 |
| Published | 2005-7-4 |
| DOI | 10.1016/j.febslet.2005.05.028 |
| PII | S0014-5793(05)00636-8 |
| PMID | 15953603 |
| MeSH | Active Transport, Cell Nucleus / drug effects Animals Cell Nucleus / chemistry Cell Nucleus / metabolism* Constitutive Androstane Receptor Cytochrome P-450 CYP2B1 / genetics Cytochrome P-450 CYP2B1 / metabolism* Down-Regulation Liver / drug effects* Liver / pathology Liver Neoplasms / metabolism* Male Mice Phenobarbital / pharmacology* Precancerous Conditions / metabolism* Rats Receptors, Cytoplasmic and Nuclear / analysis Receptors, Cytoplasmic and Nuclear / genetics Receptors, Cytoplasmic and Nuclear / metabolism* Transcription Factors / analysis Transcription Factors / genetics Transcription Factors / metabolism* Transcriptional Activation / drug effects |
| IF | 3.057 |
| Times Cited | 9 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Policy sources |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | P450 2B1 (CYP2B1) cDNA (RDB01245) |