RRC ID 20918
著者 Hameed A, Bennett E, Ciani B, Hoebers LP, Milner R, Lawrie A, Francis SE, Grierson AJ.
タイトル No evidence for cardiac dysfunction in Kif6 mutant mice.
ジャーナル PLoS One
Abstract A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction. No clear biological or physiological data exist for Kif6. We sought to investigate the impact of a deleterious KIF6 mutation on cardiac function in mice. Kif6 mutant mice were generated and verified. Cardiac function was assessed by serial echocardiography at baseline, after ageing and after exercise. Lipid levels were also measured. No discernable adverse lipid or cardiac phenotype was detected in Kif6 mutant mice. These data suggest that dysfunction of Kif6 is linked to other more complex biological/biochemical parameters or is unlikely to be of material consequence in cardiac function.
巻・号 8(1)
ページ e54636
公開日 2013-1-1
DOI 10.1371/journal.pone.0054636
PII PONE-D-12-28992
PMID 23355886
PMC PMC3552957
MeSH Animals Echocardiography Heart / physiopathology* Humans Kinesins / genetics Kinesins / metabolism* Lipids / blood* Mice Mice, Mutant Strains Mutation* Myocardial Infarction* / blood Myocardial Infarction* / genetics Myocardial Infarction* / physiopathology
IF 2.74
引用数 3
WOS 分野 CARDIAC & CARDIOVASCULAR SYSTEMS
リソース情報
実験動物マウス RBRC03194