論文 - 詳細
RRC ID | 20918 |
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著者 | Hameed A, Bennett E, Ciani B, Hoebers LP, Milner R, Lawrie A, Francis SE, Grierson AJ. |
タイトル | No evidence for cardiac dysfunction in Kif6 mutant mice. |
ジャーナル | PLoS One |
Abstract |
A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction. No clear biological or physiological data exist for Kif6. We sought to investigate the impact of a deleterious KIF6 mutation on cardiac function in mice. Kif6 mutant mice were generated and verified. Cardiac function was assessed by serial echocardiography at baseline, after ageing and after exercise. Lipid levels were also measured. No discernable adverse lipid or cardiac phenotype was detected in Kif6 mutant mice. These data suggest that dysfunction of Kif6 is linked to other more complex biological/biochemical parameters or is unlikely to be of material consequence in cardiac function. |
巻・号 | 8(1) |
ページ | e54636 |
公開日 | 2013-1-1 |
DOI | 10.1371/journal.pone.0054636 |
PII | PONE-D-12-28992 |
PMID | 23355886 |
PMC | PMC3552957 |
MeSH | Animals Echocardiography Heart / physiopathology* Humans Kinesins / genetics Kinesins / metabolism* Lipids / blood* Mice Mice, Mutant Strains Mutation* Myocardial Infarction* / blood Myocardial Infarction* / genetics Myocardial Infarction* / physiopathology |
IF | 2.74 |
引用数 | 3 |
WOS 分野 | CARDIAC & CARDIOVASCULAR SYSTEMS |
リソース情報 | |
実験動物マウス | RBRC03194 |