RRC ID 21267
著者 Li W, Hofer MJ, Noçon AL, Manders P, Campbell IL.
タイトル Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice.
ジャーナル Virology
Abstract The role of IRF7 in the host response to lymphocytic choriomeningitis virus (LCMV) Armstrong 53b infection of mice was investigated. Intracranial infection of IRF7 KO mice was associated with delayed onset of LCM, increased survival and significantly reduced expression of the Ifng gene in the brain but not in the periphery. IRF7 KO mice showed impaired control of LCMV replication and delayed clearance of LCMV. Similar numbers of activated anti-LCMV-GP(33-41) CD8+ T cells were present in the brain and spleens of infected WT and IRF7 KO mice. While plasma IFN-β was increased to similar levels, IFN-α was markedly reduced in IRF7 KO compared with WT mice. Compared with IFN-β, IFN-α was a less potent inhibitor of LCMV infection in vitro. In conclusion, IRF7 (1) is required for the early innate control of LCMV infection, likely through the regulation of the appropriate type I IFN response, and (2) is not required for the antiviral CD8+ T cell-dependent clearance of LCMV from infected tissues.
巻・号 439(2)
ページ 152-62
公開日 2013-5-10
DOI 10.1016/j.virol.2013.02.015
PII S0042-6822(13)00103-7
PMID 23490048
MeSH Animals Brain / immunology Brain / pathology CD8-Positive T-Lymphocytes / immunology Disease Models, Animal Interferon Regulatory Factor-7 / metabolism* Interferon-alpha / blood Interferon-beta / blood Lymphocytic Choriomeningitis / immunology* Lymphocytic Choriomeningitis / pathology Lymphocytic Choriomeningitis / virology* Lymphocytic choriomeningitis virus / immunology* Mice Mice, Inbred C57BL Mice, Knockout Spleen / immunology Spleen / pathology Survival Analysis
IF 2.819
引用数 10
WOS 分野 VIROLOGY
リソース情報
実験動物マウス RBRC01420