RRC ID 21816
Author Karpowicz P, Zhang Y, Hogenesch JB, Emery P, Perrimon N.
Title The circadian clock gates the intestinal stem cell regenerative state.
Journal Cell Rep
Abstract The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells. ISCs from diverse animals are remarkably similar, and the Wnt, Notch, and Hippo signaling pathways, important regulators of mammalian ISCs, are conserved from flies to humans. Unexpectedly, we identified the transcription factor period, a component of the circadian clock, to be critical for regeneration, which itself follows a circadian rhythm. We discovered hundreds of transcripts that are regulated by the clock during intestinal regeneration, including components of stress response and regeneration pathways. Disruption of clock components leads to arrhythmic ISC divisions, revealing their underappreciated role in the healing process.
Volume 3(4)
Pages 996-1004
Published 2013-4-25
DOI 10.1016/j.celrep.2013.03.016
PII S2211-1247(13)00123-X
PMID 23583176
PMC PMC3982394
MeSH Animals Circadian Clocks* Circadian Rhythm Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Interphase Intestines / cytology Intestines / physiology Period Circadian Proteins / genetics Period Circadian Proteins / metabolism* Regeneration Signal Transduction Stem Cells / cytology* Stem Cells / metabolism Transcription, Genetic
IF 8.109
Times Cited 61
Drosophila 8727R-1