論文 - 詳細
| RRC ID | 21816 |
|---|---|
| 著者 | Karpowicz P, Zhang Y, Hogenesch JB, Emery P, Perrimon N. |
| タイトル | The circadian clock gates the intestinal stem cell regenerative state. |
| ジャーナル | Cell Rep |
| Abstract |
The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells. ISCs from diverse animals are remarkably similar, and the Wnt, Notch, and Hippo signaling pathways, important regulators of mammalian ISCs, are conserved from flies to humans. Unexpectedly, we identified the transcription factor period, a component of the circadian clock, to be critical for regeneration, which itself follows a circadian rhythm. We discovered hundreds of transcripts that are regulated by the clock during intestinal regeneration, including components of stress response and regeneration pathways. Disruption of clock components leads to arrhythmic ISC divisions, revealing their underappreciated role in the healing process. |
| 巻・号 | 3(4) |
| ページ | 996-1004 |
| 公開日 | 2013-4-25 |
| DOI | 10.1016/j.celrep.2013.03.016 |
| PII | S2211-1247(13)00123-X |
| PMID | 23583176 |
| PMC | PMC3982394 |
| MeSH | Animals Circadian Clocks* Circadian Rhythm Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Interphase Intestines / cytology Intestines / physiology Period Circadian Proteins / genetics Period Circadian Proteins / metabolism* Regeneration Signal Transduction Stem Cells / cytology* Stem Cells / metabolism Transcription, Genetic |
| IF | 8.109 |
| 引用数 | 61 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 8727R-1 |