RRC ID 21833
著者 Ma Y, Chen Z, Jin Y, Liu W.
タイトル Identification of a histone acetyltransferase as a novel regulator of Drosophila intestinal stem cells.
ジャーナル FEBS Lett
Abstract One of the major challenges in stem cell research is to decipher the controlling mechanisms/genes of stem cell homeostasis. Through an RNAi mediated genetic screen of living animals, we identified an evolutionarily conserved histone acetyltransferase Atac2 as a novel regulator of Drosophila intestinal stem cells (ISCs). Expression of Atac2-RNAi or a dominant negative allele of Atac2 generated more ISCs, while excessive Atac2 or a histone deacetylase inhibitor promoted ISC differentiation without affecting ISC survival or lineage specification. These findings extend our knowledge of epigenetic mechanisms in stem cell regulation.
巻・号 587(10)
ページ 1489-95
公開日 2013-5-21
DOI 10.1016/j.febslet.2013.03.013
PII S0014-5793(13)00224-X
PMID 23535028
MeSH Adult Stem Cells / enzymology Adult Stem Cells / physiology* Animals Animals, Genetically Modified Cell Differentiation / drug effects Cell Differentiation / genetics Cell Lineage / drug effects Cell Lineage / genetics Cell Proliferation / drug effects Cell Survival / drug effects Cell Survival / genetics Cells, Cultured Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila Proteins / physiology* Drosophila melanogaster* / embryology Drosophila melanogaster* / enzymology Drosophila melanogaster* / genetics Enzyme Inhibitors / pharmacology Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Histone Acetyltransferases / antagonists & inhibitors Histone Acetyltransferases / genetics Histone Acetyltransferases / metabolism Histone Acetyltransferases / physiology* Homeostasis / genetics Homeostasis / physiology Intestinal Mucosa / cytology Intestinal Mucosa / enzymology Intestinal Mucosa / physiology* Transfection
IF 3.057
引用数 6
WOS 分野 BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ショウジョウバエ 31237R-2 4107R-1