RRC ID 21834
Author Nelson B, Freisinger T, Ishii K, Okado K, Shinzawa N, Fukumoto S, Kanuka H.
Title Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila.
Journal Biochem Biophys Res Commun
Abstract Upon microbial invasion the innate immune system of Drosophila melanogaster mounts a response that comes in two distinct but complimentary forms, humoral and cellular. A screen to find genes capable of conferring resistance to the Gram-positive Staphylococcus aureus upon ectopic expression in immune response tissues uncovered imd gene. This resistance was not dependent on cellular defenses but rather likely a result of upregulation of the humoral response through increased expression of antimicrobial peptides, including a Toll pathway reporter gene drosomycin. Taken together it appears that Imd pathway is capable of playing a role in resistance to the Gram-positive S. aureus, counter to notions of traditional roles of the Imd pathway thought largely to responsible for resistance to Gram-negative bacteria.
Volume 430(3)
Pages 1120-5
Published 2013-1-18
DOI 10.1016/j.bbrc.2012.12.027
PII S0006-291X(12)02356-X
PMID 23261474
MeSH Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / immunology* Drosophila melanogaster / microbiology* Hemocytes / immunology* Immunity, Humoral / genetics Immunity, Humoral / immunology* Signal Transduction Staphylococcus aureus / immunology*
IF 2.985
Times Cited 1
Drosophila 10520R-1 5576R-1 4909R-1 1388R-1 16910R-4 12297R-1