| RRC ID |
21886
|
| Author |
Park S, Park SH, Baek JY, Jy YJ, Kim KS, Roth J, Cho JW, Choe KM.
|
| Title |
Protein O-GlcNAcylation regulates Drosophila growth through the insulin signaling pathway.
|
| Journal |
Cell Mol Life Sci
|
| Abstract |
Modification of nuclear and cytosolic proteins by O-linked N-acetylglucosamine (O-GlcNAcylation) is ubiquitous in cells. The in vivo function of the protein O-GlcNAcylation, however, is not well understood. Here, we manipulated the cellular O-GlcNAcylation level in Drosophila and found that it promotes developmental growth by enhancing insulin signaling. This increase in growth is due mainly to cell growth and not to cell proliferation. Our data suggest that the increase in the insulin signaling activity is mediated, at least in part, through O-GlcNAcylation of Akt. These results indicate that O-GlcNAcylation is one of the crucial mechanisms involved in control of insulin signaling during Drosophila development.
|
| Volume |
68(20)
|
| Pages |
3377-84
|
| Published |
2011-10-1
|
| DOI |
10.1007/s00018-011-0640-7
|
| PMID |
21365280
|
| MeSH |
Animals
Blotting, Western
Body Composition
Cell Proliferation
Drosophila / growth & development*
Drosophila / metabolism*
Glycosylation
Immunoenzyme Techniques
Immunoprecipitation
Insulin / metabolism*
N-Acetylglucosaminyltransferases / antagonists & inhibitors
N-Acetylglucosaminyltransferases / genetics
N-Acetylglucosaminyltransferases / metabolism
Phosphorylation
Protein Processing, Post-Translational*
Proto-Oncogene Proteins c-akt / metabolism*
RNA, Small Interfering / genetics
Signal Transduction*
|
| IF |
6.496
|
| Times Cited |
11
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Drosophila |
5671R-1
4006R-3 |
