論文 - 詳細
| RRC ID | 21889 |
|---|---|
| 著者 | Baek SH, Kwon YC, Lee H, Choe KM. |
| タイトル | Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
A wound induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis. Here, we use myosin localization to demonstrate that Rac1, Cdc42, and Rho1 are each required for cell polarization and directional sensing of the wound. The three GTPases are also required for actin cable formation at the wound leading edge. Rac1, Cdc42, and Rho1 act upstream of c-Jun N-terminal kinase (JNK) to organize actin assembly. These results highlight the similarities between the molecular mechanism of Drosophila wound healing and those of Drosophila embryonic dorsal closure and the chemotactic response of Dictyostelium and leukocytes. |
| 巻・号 | 394(3) |
| ページ | 488-92 |
| 公開日 | 2010-4-9 |
| DOI | 10.1016/j.bbrc.2010.02.124 |
| PII | S0006-291X(10)00358-X |
| PMID | 20184864 |
| MeSH | Actins / metabolism Animals Cell Polarity* Drosophila Proteins / genetics Drosophila Proteins / physiology* Drosophila melanogaster / enzymology Drosophila melanogaster / physiology* JNK Mitogen-Activated Protein Kinases / metabolism Myosins / metabolism Wound Healing* cdc42 GTP-Binding Protein / genetics cdc42 GTP-Binding Protein / physiology* rac GTP-Binding Proteins / genetics rac GTP-Binding Proteins / physiology* rho GTP-Binding Proteins / genetics rho GTP-Binding Proteins / physiology* |
| IF | 2.985 |
| 引用数 | 23 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | 2248R-2 |