論文 - 詳細
| RRC ID | 21891 |
|---|---|
| 著者 | Herranz H, Hong X, Pérez L, Ferreira A, Olivieri D, Cohen SM, Milán M. |
| タイトル | The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. |
| ジャーナル | EMBO J |
| Abstract |
MicroRNAs (miRNAs) have been implicated in cell-cycle regulation and in some cases shown to have a role in tissue growth control. Depletion of miRNAs was found to have an effect on tissue growth rates in the wing primordium of Drosophila, a highly proliferative epithelium. Dicer-1 (Dcr-1) is a double-stranded RNAseIII essential for miRNA biogenesis. Adult cells lacking dcr-1, or with reduced dcr-1 activity, were smaller than normal cells and gave rise to smaller wings. dcr-1 mutant cells showed evidence of being susceptible to competition by faster growing cells in vivo and the miRNA machinery was shown to promote G(1)-S transition. We present evidence that Dcr-1 acts by regulating the TRIM-NHL protein Mei-P26, which in turn regulates dMyc protein levels. Mei-P26 is a direct target of miRNAs, including the growth-promoting bantam miRNA. Thus, regulation of tissue growth by the miRNA pathway involves a double repression mechanism to control dMyc protein levels in a highly proliferative and growing epithelium. |
| 巻・号 | 29(10) |
| ページ | 1688-98 |
| 公開日 | 2010-5-19 |
| DOI | 10.1038/emboj.2010.69 |
| PII | emboj201069 |
| PMID | 20400939 |
| PMC | PMC2876971 |
| MeSH | Animals Cell Cycle Cell Proliferation Drosophila Proteins / metabolism* Drosophila melanogaster E2F Transcription Factors / metabolism Epithelium / metabolism Female G1 Phase Genotype Male MicroRNAs / metabolism* Models, Biological Proto-Oncogene Proteins c-myc / metabolism* RNA Helicases / metabolism* Ribonuclease III / metabolism* S Phase Wings, Animal / metabolism |
| IF | 9.889 |
| 引用数 | 33 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 12218R-1 12218R-3 |