論文 - 詳細
| RRC ID | 21945 |
|---|---|
| 著者 | Osman D, Buchon N, Chakrabarti S, Huang YT, Su WC, Poidevin M, Tsai YC, Lemaitre B. |
| タイトル | Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division. |
| ジャーナル | J Cell Sci |
| Abstract |
The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is involved in the regulation of intestinal stem cell (ISC) activity to ensure a continuous renewal of the adult Drosophila midgut. Three ligands, Unpaired 1, Unpaired 2 and Unpaired 3 (Upd1, Upd2 and Upd3, respectively) are known to activate the JAK/STAT pathway in Drosophila. Using newly generated upd mutants and cell-specific RNAi, we showed that Upd1 is required throughout the fly life to maintain basal turnover of the midgut epithelium by controlling ISC maintenance in an autocrine manner. A role of Upd2 and Upd3 in basal conditions is discernible only in old gut, where they contribute to increased ISC abnormal division. Finally, upon an acute stress such as oral bacterial infection, we showed that Upd3 is released from enterocytes and has an additive effect with Upd2 to promote rapid epithelial regeneration. Taken together, our results show that Upd ligands are required to maintain the midgut homeostasis under both normal and pathological states. |
| 巻・号 | 125(Pt 24) |
| ページ | 5944-9 |
| 公開日 | 2012-12-15 |
| DOI | 10.1242/jcs.113100 |
| PII | jcs.113100 |
| PMID | 23038775 |
| MeSH | Animals Autocrine Communication Cell Differentiation / physiology Cell Division Cell Growth Processes / physiology Drosophila / cytology* Drosophila / genetics Drosophila / metabolism Drosophila / microbiology Drosophila Proteins / biosynthesis Drosophila Proteins / genetics Female Intestinal Mucosa / metabolism Intestines / cytology* Intestines / microbiology Janus Kinases / metabolism Paracrine Communication Pectobacterium carotovorum / physiology STAT Transcription Factors / metabolism Stem Cells / cytology* Transcription Factors / biosynthesis Transcription Factors / genetics |
| IF | 4.573 |
| 引用数 | 71 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |