論文 - 詳細
| RRC ID | 21956 |
|---|---|
| 著者 | Schulz JG, Ceulemans H, Caussinus E, Baietti MF, Affolter M, Hassan BA, David G. |
| タイトル | Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels. |
| ジャーナル | EMBO Rep |
| Abstract |
Here we identify a new role for Syndecan (Sdc), the only transmembrane heparan sulphate proteoglycan in Drosophila, in tracheal development. Sdc is required cell autonomously for efficient directed migration and fusion of dorsal branch cells, but not for dorsal branch formation per se. The cytoplasmic domain of Sdc is dispensable, indicating that Sdc does not transduce a signal by itself. Although the branch-specific phenotype of sdc mutants resembles those seen in the absence of Slit/Robo2 signalling, genetic interaction experiments indicate that Sdc also helps to suppress Slit/Robo2 signalling. We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion. |
| 巻・号 | 12(10) |
| ページ | 1039-46 |
| 公開日 | 2011-9-30 |
| DOI | 10.1038/embor.2011.153 |
| PII | embor2011153 |
| PMID | 21836636 |
| PMC | PMC3185339 |
| MeSH | Animals Base Sequence Cell Movement* / genetics Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / cytology Drosophila melanogaster / embryology Drosophila melanogaster / growth & development* Gene Expression Regulation Gene Order Molecular Sequence Data Nerve Tissue Proteins / metabolism* Phenotype Protein Stability Receptors, Immunologic / metabolism* Sequence Alignment Signal Transduction Syndecans / genetics Syndecans / metabolism* Trachea / metabolism |
| IF | 7.497 |
| 引用数 | 7 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | |