Reference - Detail
| RRC ID | 21979 |
|---|---|
| Author | Bajzek C, Rice AM, Andreazza S, Dushay MS. |
| Title | Coagulation and survival in Drosophila melanogaster fondue mutants. |
| Journal | J Insect Physiol |
| Abstract |
Drosophila larval coagulation factors have been identified in vitro. Better understanding of insect hemolymph coagulation calls for experiments in vivo. We have characterized a fondue (fon) mutation and null alleles isolated by imprecise excision of a transposable element. Loss of fon was pupal lethal, but adults could be recovered by expressing the UAS::fonGFP construct of Lindgren et al. (2008). Despite their lethality, fon mutations did not affect larval survival after wounding either when tested alone or in combination with a mutation in the hemolectin clotting factor gene. This reinforces the idea of redundant hemostatic mechanisms in Drosophila larvae, and independent pleiotropic functions of the fondue protein in coagulation and a vital process in metamorphosis. |
| Volume | 58(10) |
| Pages | 1376-81 |
| Published | 2012-10-1 |
| DOI | 10.1016/j.jinsphys.2012.07.013 |
| PII | S0022-1910(12)00188-6 |
| PMID | 22885376 |
| MeSH | Animals Blood Proteins / genetics* Drosophila Proteins / genetics* Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Female Hemolymph / physiology* Hemostasis* Larva / physiology Male Mutation |
| IF | 2.246 |
| Times Cited | 7 |
| WOS Category | ENTOMOLOGY ZOOLOGY PHYSIOLOGY |
| Resource | |
| Drosophila | |