論文 - 詳細
| RRC ID | 21997 |
|---|---|
| 著者 | Okamoto N, Nakamori R, Murai T, Yamauchi Y, Masuda A, Nishimura T. |
| タイトル | A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila. |
| ジャーナル | Genes Dev |
| Abstract |
Members of the insulin peptide family have conserved roles in the regulation of growth and metabolism in a wide variety of metazoans. Drosophila insulin-like peptides (Dilps) promote tissue growth through the single insulin-like receptor (InR). Despite the important role of Dilps in nutrient-dependent growth control, the molecular mechanism that regulates the activity of circulating Dilps is not well understood. Here, we report the function of a novel secreted decoy of InR (SDR) as a negative regulator of insulin signaling. SDR is predominantly expressed in glia and is secreted into the hemolymph. Larvae lacking SDR grow at a faster rate, thereby increasing adult body size. Conversely, overexpression of SDR reduces body growth non-cell-autonomously. SDR is structurally similar to the extracellular domain of InR and interacts with several Dilps in vitro independent of Imp-L2, the ortholog of the mammalian insulin-like growth factor-binding protein 7 (IGFBP7). We further demonstrate that SDR is constantly secreted into the hemolymph independent of nutritional status and is essential for adjusting insulin signaling under adverse food conditions. We propose that Drosophila uses a secreted decoy to fine-tune systemic growth against fluctuations of circulating insulin levels. |
| 巻・号 | 27(1) |
| ページ | 87-97 |
| 公開日 | 2013-1-1 |
| DOI | 10.1101/gad.204479.112 |
| PII | 27/1/87 |
| PMID | 23307869 |
| PMC | PMC3553286 |
| MeSH | Animals Drosophila Proteins / metabolism* Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental Hemolymph / metabolism Insulin / metabolism* Larva Neuroglia / metabolism Receptor Protein-Tyrosine Kinases / metabolism Signal Transduction* Somatomedins / metabolism* |
| IF | 9.527 |
| 引用数 | 60 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY GENETICS & HEREDITY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#206122 |