論文 - 詳細
| RRC ID | 22020 |
|---|---|
| 著者 | Araye Q, Sawamura K. |
| タイトル | Genetic decay of balancer chromosomes in Drosophila melanogaster. |
| ジャーナル | Fly (Austin) |
| Abstract |
Theoretical considerations predict that balancer chromosomes in Drosophila melanogaster should accumulate numerous deleterious mutations with time. We counted the number of recessive lethal mutations on two balancer chromosomes from the In(2LR)SM1/In(2LR)Pm strain maintained in our lab, after making the balancers heterozygous with deficiencies from second-chromosome Kyoto Deficiency kit strains. We detected 10 recessive lethal mutations in the balancer In(2LR)Pm, which is consistent with the mutation rate estimated previously. However, we detected only three mutations, a significantly smaller number, in the balancer In(2LR)SM1, although this may be an artifact. In conclusion, we observed genetic decay over an estimable timescale by using balancers with historical records. Thus, balancers of any strain may have accumulated many unidentified recessive lethal mutations. |
| 巻・号 | 7(3) |
| ページ | 184-6 |
| 公開日 | 2013-1-1 |
| DOI | 10.4161/fly.24466 |
| PII | 24466 |
| PMID | 23648996 |
| PMC | PMC4049851 |
| MeSH | Animals Animals, Genetically Modified Chromosomes, Insect* Drosophila melanogaster / genetics* Female Genes, Lethal* Genes, Recessive* Male Mutation* |
| IF | 1.204 |
| 引用数 | 2 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | second-chromosome Kyoto Deficiency kit strains |