Reference - Detail
| RRC ID | 22707 |
|---|---|
| Author | Messaritou G, Leptourgidou F, Franco M, Skoulakis EM. |
| Title | A third functional isoform enriched in mushroom body neurons is encoded by the Drosophila 14-3-3zeta gene. |
| Journal | FEBS Lett |
| Abstract |
14-3-3 proteins are highly conserved across eukaryotes, typically encoded by multiple genes in most species. Drosophila has only two such genes, 14-3-3zeta (leo), encoding two isoforms LEOI and LEOII, and 14-3-3epsilon. We report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas, thus increasing 14-3-3 diversity in Drosophila. Furthermore, we used a novel approach of spatially restricted leo abrogation by RNA-interference and revealed differential LEO distribution in adult heads, with LEOIII enrichment in neurons essential for learning and memory in Drosophila. |
| Volume | 583(17) |
| Pages | 2934-8 |
| Published | 2009-9-3 |
| DOI | 10.1016/j.febslet.2009.08.003 |
| PII | S0014-5793(09)00613-9 |
| PMID | 19665025 |
| MeSH | 14-3-3 Proteins / genetics 14-3-3 Proteins / metabolism* Amino Acid Sequence Animals Brain / cytology Brain / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster* / anatomy & histology Drosophila melanogaster* / genetics Drosophila melanogaster* / metabolism Molecular Sequence Data Neurons / cytology Neurons / metabolism* Protein Isoforms / genetics Protein Isoforms / metabolism* Sequence Alignment |
| IF | 3.057 |
| Times Cited | 11 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Drosophila | |