RRC ID |
22811
|
著者 |
Kurokawa K, Hamamoto H, Matsuo M, Nishida S, Yamane N, Lee BL, Murakami K, Maki H, Sekimizu K.
|
タイトル |
Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model.
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ジャーナル |
Antimicrob Agents Chemother
|
Abstract |
The availability of a silkworm larva infection model to evaluate the therapeutic effectiveness of antibiotics was examined. The 50% effective doses (ED50) of D-cycloserine against the Staphylococcus aureus ddlA mutant-mediated killing of larvae were remarkably lower than those against the parental strain-mediated killing of larvae. Changes in MICs and ED50 of other antibiotics were negligible, suggesting that these alterations are d-cycloserine selective. Therefore, this model is useful for selecting desired compounds based on their therapeutic effectiveness during antibiotic development.
|
巻・号 |
53(9)
|
ページ |
4025-7
|
公開日 |
2009-9-1
|
DOI |
10.1128/AAC.00200-09
|
PII |
AAC.00200-09
|
PMID |
19546371
|
PMC |
PMC2737873
|
MeSH |
Animals
Anti-Bacterial Agents / pharmacology*
Bombyx / microbiology*
Cephalosporins / pharmacology
Chloramphenicol / pharmacology
Cycloserine / pharmacology*
Inhibitory Concentration 50
Larva / immunology
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects*
Tetracycline / pharmacology
Vancomycin / pharmacology
|
IF |
4.904
|
引用数 |
12
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
MICROBIOLOGY
|
リソース情報 |
カイコ |
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