RRC ID 231
著者 Fukamachi S, Sugimoto M, Mitani H, Shima A.
タイトル Somatolactin selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells in medaka.
ジャーナル Proc Natl Acad Sci U S A
Abstract Species-specific colors and patterns on animal body surfaces are determined primarily by neural-crest-derived pigment cells in the skin (chromatophores). However, even closely related species display widely differing patterns. These contrasting aspects of chromatophores (i.e., the fixed developmental control within species and extreme diversity among species) seem to be a curious and suitable subject for understanding evolution and diversity of organisms. Here we identify a gene responsible for medaka "color interfere" mutants by positional cloning. These mutants do not show any obvious morphological and physiological defects other than defects in chromatophore proliferation and morphogenesis. The mutation has been identified as an 11-base deletion in somatolactin, which causes truncation 91 aa upstream of the C terminus of the protein's 230 aa. Somatolactin transcription changed dramatically during morphological body color adaptation to different backgrounds. This genetic evidence explains somatolactin function. Studying this mutant will provide further insights into the development and regulation of chromatophores and clues for reassessing other functions of somatolactin suggested in other fish.
巻・号 101(29)
ページ 10661-6
公開日 2004-7-20
DOI 10.1073/pnas.0401278101
PII 0401278101
PMID 15249680
PMC PMC489991
MeSH Adaptation, Physiological Amino Acid Sequence Animals Base Sequence Cell Division / physiology* Chromatophores / cytology Chromatophores / physiology* Cloning, Molecular Fish Proteins Gene Expression Regulation Glycoproteins / classification Glycoproteins / genetics Glycoproteins / metabolism* Molecular Sequence Data Morphogenesis / physiology* Neural Crest / cytology* Neural Crest / physiology Oryzias / anatomy & histology Oryzias / genetics Oryzias / growth & development* Oryzias / physiology Phylogeny Pigmentation / genetics Pigmentation / physiology Pituitary Hormones / classification Pituitary Hormones / genetics Pituitary Hormones / metabolism* Sequence Alignment Sequence Analysis, DNA Transcription, Genetic
IF 9.412
引用数 66
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
メダカ ci (MT15) HNI-II (IB176) BAC Grey(BBRRcici) (MT1123)