RRC ID |
231
|
著者 |
Fukamachi S, Sugimoto M, Mitani H, Shima A.
|
タイトル |
Somatolactin selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells in medaka.
|
ジャーナル |
Proc Natl Acad Sci U S A
|
Abstract |
Species-specific colors and patterns on animal body surfaces are determined primarily by neural-crest-derived pigment cells in the skin (chromatophores). However, even closely related species display widely differing patterns. These contrasting aspects of chromatophores (i.e., the fixed developmental control within species and extreme diversity among species) seem to be a curious and suitable subject for understanding evolution and diversity of organisms. Here we identify a gene responsible for medaka "color interfere" mutants by positional cloning. These mutants do not show any obvious morphological and physiological defects other than defects in chromatophore proliferation and morphogenesis. The mutation has been identified as an 11-base deletion in somatolactin, which causes truncation 91 aa upstream of the C terminus of the protein's 230 aa. Somatolactin transcription changed dramatically during morphological body color adaptation to different backgrounds. This genetic evidence explains somatolactin function. Studying this mutant will provide further insights into the development and regulation of chromatophores and clues for reassessing other functions of somatolactin suggested in other fish.
|
巻・号 |
101(29)
|
ページ |
10661-6
|
公開日 |
2004-7-20
|
DOI |
10.1073/pnas.0401278101
|
PII |
0401278101
|
PMID |
15249680
|
PMC |
PMC489991
|
MeSH |
Adaptation, Physiological
Amino Acid Sequence
Animals
Base Sequence
Cell Division / physiology*
Chromatophores / cytology
Chromatophores / physiology*
Cloning, Molecular
Fish Proteins
Gene Expression Regulation
Glycoproteins / classification
Glycoproteins / genetics
Glycoproteins / metabolism*
Molecular Sequence Data
Morphogenesis / physiology*
Neural Crest / cytology*
Neural Crest / physiology
Oryzias / anatomy & histology
Oryzias / genetics
Oryzias / growth & development*
Oryzias / physiology
Phylogeny
Pigmentation / genetics
Pigmentation / physiology
Pituitary Hormones / classification
Pituitary Hormones / genetics
Pituitary Hormones / metabolism*
Sequence Alignment
Sequence Analysis, DNA
Transcription, Genetic
|
IF |
9.412
|
引用数 |
66
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
|
リソース情報 |
メダカ |
ci (MT15)
HNI-II (IB176)
BAC
Grey(BBRRcici) (MT1123) |