論文 - 詳細
| RRC ID | 2402 |
|---|---|
| 著者 | Nakatomi M, Morita I, Eto K, Ota MS. |
| タイトル | Sonic hedgehog signaling is important in tooth root development. |
| ジャーナル | J Dent Res |
| Abstract |
Hertwig's epithelial root sheath (HERS) is important for tooth root formation, but the molecular basis for the signaling of root development remains uncertain. We hypothesized that Sonic hedgehog (Shh) signaling is involved in the HERS function, because it mediates epithelial-mesenchymal interactions during embryonic odontogenesis. We examined the gene expression patterns of Shh signaling in murine developing molar roots. Shh and Patched2 transcripts were identified in the HERS, whereas Patched1, Smoothened, and Gli1 were expressed in the proliferative dental mesenchyme in addition to the HERS. To confirm whether Shh signaling physiologically functions in vivo, we analyzed mesenchymal dysplasia (mes) mice carrying an abnormal C-terminus of the PATCHED1 protein. In the mutant, cell proliferation was repressed around the HERS at 1 wk. Moreover, the molar eruption was disturbed, and all roots were shorter than those in control littermates at 4 wks. These results indicate that Shh signaling is important in tooth root development. Abbreviations used: BrdU, 5-bromo-2'-deoxyuridine; HERS, Hertwig's epithelial root sheath; NFI-C/CTF, nuclear factor Ic/CAAT box transcription factor; PCNA, proliferating cell nuclear antigen; Ptc, patched; Shh, sonic hedgehog; Smo, smoothened. |
| 巻・号 | 85(5) |
| ページ | 427-31 |
| 公開日 | 2006-5-1 |
| DOI | 10.1177/154405910608500506 |
| PII | 85/5/427 |
| PMID | 16632755 |
| MeSH | Animals Cell Proliferation Epithelium Gene Expression Regulation, Developmental Hedgehog Proteins In Situ Hybridization Kruppel-Like Transcription Factors / genetics Kruppel-Like Transcription Factors / physiology Mesoderm / pathology Mice Mice, Inbred C57BL Mice, Mutant Strains Morphogenesis / genetics Odontogenesis / genetics* Patched Receptors Patched-1 Receptor Patched-2 Receptor Receptors, Cell Surface / genetics Receptors, Cell Surface / physiology Signal Transduction Tooth Eruption / genetics Tooth Root / growth & development* Trans-Activators / genetics* Trans-Activators / physiology* Zinc Finger Protein GLI1 |
| IF | 4.914 |
| 引用数 | 111 |
| WOS 分野 | DENTISTRY, ORAL SURGERY & MEDICINE |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00619 |