Reference - Detail
| RRC ID | 2406 |
|---|---|
| Author | Sugimoto M, Abe K. |
| Title | X chromosome reactivation initiates in nascent primordial germ cells in mice. |
| Journal | PLoS Genet |
| Abstract |
During primordial germ cell (PGC) development, epigenetic reprogramming events represented by X chromosome reactivation and erasure of genomic imprinting are known to occur. Although precise timing is not given, X reactivation is thought to take place over a short period of time just before initiation of meiosis. Here, we show that the cessation of Xist expression commences in nascent PGCs, and re-expression of some X-linked genes begins in newly formed PGCs. The X reactivation process was not complete in E14.5 PGCs, indicating that X reactivation in developing PGCs occurs over a prolonged period. These results set the reactivation timing much earlier than previously thought and suggest that X reactivation may involve slow passive steps. |
| Volume | 3(7) |
| Pages | e116 |
| Published | 2007-7-1 |
| DOI | 10.1371/journal.pgen.0030116 |
| PII | 07-PLGE-RA-0234 |
| PMID | 17676999 |
| PMC | PMC1950944 |
| MeSH | Alleles Animals Epigenesis, Genetic Female Gene Expression Regulation, Developmental* Germ Cells / metabolism In Situ Hybridization, Fluorescence Kinetics Male Mice Mice, Transgenic Models, Genetic Time Factors X Chromosome* X Chromosome Inactivation* |
| IF | 5.175 |
| Times Cited | 121 |
| WOS Category | GENETICS & HEREDITY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC00209 RBRC01739 |