Reference - Detail
| RRC ID | 2411 |
|---|---|
| Author | Nakao K, Morita R, Saji Y, Ishida K, Tomita Y, Ogawa M, Saitoh M, Tomooka Y, Tsuji T. |
| Title | The development of a bioengineered organ germ method. |
| Journal | Nat Methods |
| Abstract |
To bioengineer ectodermal organs such as teeth and whisker follicles, we developed a three-dimensional organ-germ culture method. The bioengineered tooth germ generated a structurally correct tooth, after both in vitro organ culture as well as transplantation under a tooth cavity in vivo, showing penetration of blood vessels and nerve fibers. Our method provides a substantial advance in the development of bioengineered organ replacement strategies and regenerative therapies. |
| Volume | 4(3) |
| Pages | 227-30 |
| Published | 2007-3-1 |
| DOI | 10.1038/nmeth1012 |
| PII | nmeth1012 |
| PMID | 17322892 |
| MeSH | Animals Bioartificial Organs* Biomedical Engineering / methods Cell Differentiation Cells, Cultured Epithelial Cells / physiology* Mesenchymal Stem Cells / cytology* Mice Organ Culture Techniques / methods Organogenesis / physiology* Tissue Engineering / methods* Tooth / cytology* Vibrissae / cytology* |
| IF | 30.822 |
| Times Cited | 284 |
| WOS Category | BIOCHEMICAL RESEARCH METHODS |
| Resource | |
| Mice | RBRC00267 |