RRC ID 2445
Author Wilson AL, Shen YC, Babb-Clendenon SG, Rostedt J, Liu B, Barald KF, Marrs JA, Liu Q.
Title Cadherin-4 plays a role in the development of zebrafish cranial ganglia and lateral line system.
Journal Dev. Dyn.
Abstract We previously reported that cadherin-4 (also called R-cadherin) was expressed by the majority of the developing zebrafish cranial and lateral line ganglia. Cadherin-4 (Cdh4) function in the formation of these structures in zebrafish was studied using morpholino antisense technology. Differentiation of the cranial and lateral line ganglia and lateral line nerve and neuromasts of the cdh4 morphants was analyzed using multiple neural markers. We found that a subset of the morphant cranial and lateral line ganglia were disorganized, smaller, with reduced staining, and/or with altered shape compared to control embryos. Increased cell death in the morphant ganglia likely contributed to these defects. Moreover, cdh4 morphants had shorter lateral line nerves and a reduced number of neuromasts, which was likely caused by disrupted migration of the lateral line primordia. These results indicate that Cdh4 plays a role in the normal formation of the zebrafish lateral line system and a subset of the cranial ganglia.
Volume 236(3)
Pages 893-902
Published 2007-3
DOI 10.1002/dvdy.21085
PMID 17279575
PMC PMC2504752
MeSH Animals Cadherins / genetics* Cadherins / physiology Cell Adhesion Molecules / genetics Cell Adhesion Molecules / physiology Cell Differentiation / genetics Cell Differentiation / physiology Ganglia / embryology Ganglia / metabolism* Gene Expression Regulation, Developmental In Situ Hybridization Lateral Line System / embryology Lateral Line System / metabolism* Reverse Transcriptase Polymerase Chain Reaction Zebrafish / embryology Zebrafish / genetics* Zebrafish / metabolism Zebrafish Proteins / genetics* Zebrafish Proteins / physiology
IF 2.852
Times Cited 15
Zebrafish ?