| RRC ID |
2445
|
| 著者 |
Wilson AL, Shen YC, Babb-Clendenon SG, Rostedt J, Liu B, Barald KF, Marrs JA, Liu Q.
|
| タイトル |
Cadherin-4 plays a role in the development of zebrafish cranial ganglia and lateral line system.
|
| ジャーナル |
Dev Dyn
|
| Abstract |
We previously reported that cadherin-4 (also called R-cadherin) was expressed by the majority of the developing zebrafish cranial and lateral line ganglia. Cadherin-4 (Cdh4) function in the formation of these structures in zebrafish was studied using morpholino antisense technology. Differentiation of the cranial and lateral line ganglia and lateral line nerve and neuromasts of the cdh4 morphants was analyzed using multiple neural markers. We found that a subset of the morphant cranial and lateral line ganglia were disorganized, smaller, with reduced staining, and/or with altered shape compared to control embryos. Increased cell death in the morphant ganglia likely contributed to these defects. Moreover, cdh4 morphants had shorter lateral line nerves and a reduced number of neuromasts, which was likely caused by disrupted migration of the lateral line primordia. These results indicate that Cdh4 plays a role in the normal formation of the zebrafish lateral line system and a subset of the cranial ganglia.
|
| 巻・号 |
236(3)
|
| ページ |
893-902
|
| 公開日 |
2007-3-1
|
| DOI |
10.1002/dvdy.21085
|
| PMID |
17279575
|
| PMC |
PMC2504752
|
| MeSH |
Animals
Cadherins / genetics*
Cadherins / physiology
Cell Adhesion Molecules / genetics
Cell Adhesion Molecules / physiology
Cell Differentiation / genetics
Cell Differentiation / physiology
Ganglia / embryology
Ganglia / metabolism*
Gene Expression Regulation, Developmental
In Situ Hybridization
Lateral Line System / embryology
Lateral Line System / metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Zebrafish / embryology
Zebrafish / genetics*
Zebrafish / metabolism
Zebrafish Proteins / genetics*
Zebrafish Proteins / physiology
|
| IF |
3.275
|
| 引用数 |
17
|
|
WOS 分野
|
ANATOMY & MORPHOLOGY
DEVELOPMENTAL BIOLOGY
|
| リソース情報 |
| ゼブラフィッシュ |
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