RRC ID 2455
Author Novak AE, Taylor AD, Pineda RH, Lasda EL, Wright MA, Ribera AB.
Title Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes.
Journal Dev. Dyn.
Abstract Whereas it is known that voltage-gated calcium channels play important roles during development, potential embryonic roles of voltage-gated sodium channels have received much less attention. Voltage-gated sodium channels consist of pore-forming alpha-subunits (Na(v)1) and auxiliary beta-subunits. Here, we report the embryonic and larval expression patterns for all eight members of the gene family (scna) coding for zebrafish Na(v)1 proteins. We find that each scna gene displays a distinct expression pattern that is temporally and spatially dynamic during embryonic and larval stages. Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues.
Volume 235(7)
Pages 1962-73
Published 2006-7
DOI 10.1002/dvdy.20811
PMID 16615064
MeSH Amino Acid Sequence Animals Embryo, Nonmammalian / metabolism Gene Expression Regulation, Developmental Ion Channel Gating Larva / metabolism Molecular Sequence Data Myocardium / metabolism Protein Subunits / genetics Protein Subunits / metabolism Sodium Channels / genetics Sodium Channels / metabolism* Zebrafish / embryology* Zebrafish / metabolism Zebrafish Proteins / genetics Zebrafish Proteins / metabolism*
IF 2.507
Times Cited 47
Zebrafish ?