論文 - 詳細
| RRC ID | 2455 |
|---|---|
| 著者 | Novak AE, Taylor AD, Pineda RH, Lasda EL, Wright MA, Ribera AB. |
| タイトル | Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. |
| ジャーナル | Dev Dyn |
| Abstract |
Whereas it is known that voltage-gated calcium channels play important roles during development, potential embryonic roles of voltage-gated sodium channels have received much less attention. Voltage-gated sodium channels consist of pore-forming alpha-subunits (Na(v)1) and auxiliary beta-subunits. Here, we report the embryonic and larval expression patterns for all eight members of the gene family (scna) coding for zebrafish Na(v)1 proteins. We find that each scna gene displays a distinct expression pattern that is temporally and spatially dynamic during embryonic and larval stages. Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues. |
| 巻・号 | 235(7) |
| ページ | 1962-73 |
| 公開日 | 2006-7-1 |
| DOI | 10.1002/dvdy.20811 |
| PMID | 16615064 |
| MeSH | Amino Acid Sequence Animals Embryo, Nonmammalian / metabolism Gene Expression Regulation, Developmental Ion Channel Gating Larva / metabolism Molecular Sequence Data Myocardium / metabolism Protein Subunits / genetics Protein Subunits / metabolism Sodium Channels / genetics Sodium Channels / metabolism* Zebrafish / embryology* Zebrafish / metabolism Zebrafish Proteins / genetics Zebrafish Proteins / metabolism* |
| IF | 3.275 |
| 引用数 | 57 |
| WOS 分野 | ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| ゼブラフィッシュ | |