| RRC ID |
2455
|
| 著者 |
Novak AE, Taylor AD, Pineda RH, Lasda EL, Wright MA, Ribera AB.
|
| タイトル |
Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes.
|
| ジャーナル |
Dev Dyn
|
| Abstract |
Whereas it is known that voltage-gated calcium channels play important roles during development, potential embryonic roles of voltage-gated sodium channels have received much less attention. Voltage-gated sodium channels consist of pore-forming alpha-subunits (Na(v)1) and auxiliary beta-subunits. Here, we report the embryonic and larval expression patterns for all eight members of the gene family (scna) coding for zebrafish Na(v)1 proteins. We find that each scna gene displays a distinct expression pattern that is temporally and spatially dynamic during embryonic and larval stages. Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues.
|
| 巻・号 |
235(7)
|
| ページ |
1962-73
|
| 公開日 |
2006-7-1
|
| DOI |
10.1002/dvdy.20811
|
| PMID |
16615064
|
| MeSH |
Amino Acid Sequence
Animals
Embryo, Nonmammalian / metabolism
Gene Expression Regulation, Developmental
Ion Channel Gating
Larva / metabolism
Molecular Sequence Data
Myocardium / metabolism
Protein Subunits / genetics
Protein Subunits / metabolism
Sodium Channels / genetics
Sodium Channels / metabolism*
Zebrafish / embryology*
Zebrafish / metabolism
Zebrafish Proteins / genetics
Zebrafish Proteins / metabolism*
|
| IF |
3.275
|
| 引用数 |
57
|
|
WOS 分野
|
ANATOMY & MORPHOLOGY
DEVELOPMENTAL BIOLOGY
|
| リソース情報 |
| ゼブラフィッシュ |
|
