RRC ID 2646
Author Hosoe T, Iizuka T, Komai S, Wakana D, Itabashi T, Nozawa K, Fukushima K, Kawai K.
Title 4-benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300.
Journal Phytochemistry
Abstract Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification of 4-benzyl-3-phenyl-5H-furan-2-one (1) as a vasodilator and erythroglaucin (2). The structure of 1 was established on the basis of spectroscopic and chemical investigations. Compound 1 inhibited Ca2+-induced vasocintraction in aortic rings pretreated with high K+ (60mM) or norepinephrine. Finally, compound 1 did not exhibit activity against human pathogenic microorganisms.
Volume 66(23)
Pages 2776-9
Published 2005-12
DOI 10.1016/j.phytochem.2005.08.014
PII S0031-9422(05)00420-6
PMID 16213536
MeSH Animals Aorta, Thoracic / drug effects Aorta, Thoracic / physiology Benzyl Compounds / chemistry* Benzyl Compounds / isolation & purification Benzyl Compounds / pharmacology* Calcium / pharmacology Dose-Response Relationship, Drug Furans / chemistry* Furans / isolation & purification Furans / pharmacology* In Vitro Techniques Magnetic Resonance Spectroscopy Male Microbial Sensitivity Tests Molecular Structure Onygenales / chemistry* Potassium / pharmacology Rats Rats, Wistar Spectrometry, Mass, Electrospray Ionization Vasodilator Agents / chemistry* Vasodilator Agents / pharmacology*
IF 3.186
Times Cited 14
Pathogenic microorganisms IFM 40009 IFM 40215 IFM 41243 IFM 41300 IFM 41398