論文 - 詳細
RRC ID | 2650 |
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著者 | Ikeda Y, Furumai T, Igarashi Y. |
タイトル | Nocardimicins G, H and I, siderophores with muscarinic M3 receptor binding inhibitory activity from Nocardia nova JCM 6044. |
ジャーナル | J Antibiot (Tokyo) |
Abstract |
In the screening for muscarinic M3 receptor binding inhibitors from microbial secondary metabolites, the extract of Nocardia nova JCM 6044 was found to be highly active. Bioassay-guided isolation led to the identification of three siderophores, nocardimicins G (1), H (2) and I (3). Their chemical structures were determined by spectroscopic analysis using NMR and MS. 1 and 2 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with Ki values of 0.44 microM and 0.37 microM, respectively, whereas 3 showed no inhibition at 10 microM. 1 and 2 also showed weak binding inhibitory activity to the M5 receptor but not to the M1, M2 and M4 receptors at 10 microM. |
巻・号 | 58(9) |
ページ | 566-72 |
公開日 | 2005-9-1 |
DOI | 10.1038/ja.2005.77 |
PMID | 16320761 |
MeSH | Hydroxamic Acids / isolation & purification Hydroxamic Acids / pharmacology Molecular Structure Muscarinic Antagonists / chemistry Muscarinic Antagonists / isolation & purification Muscarinic Antagonists / pharmacokinetics Muscarinic Antagonists / pharmacology Nocardia / chemistry* Oxazoles / isolation & purification Oxazoles / pharmacology Receptor, Muscarinic M3 / antagonists & inhibitors* Receptor, Muscarinic M3 / metabolism Siderophores / chemistry Siderophores / isolation & purification* Siderophores / pharmacology |
IF | 2.668 |
引用数 | 11 |
WOS 分野 | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY |
リソース情報 | |
病原微生物 | JCM 6044 |