| RRC ID |
27176
|
| 著者 |
Zhou J, Wen Y, She L, Sui YN, Liu L, Richards LJ, Poo MM.
|
| タイトル |
Axon position within the corpus callosum determines contralateral cortical projection.
|
| ジャーナル |
Proc Natl Acad Sci U S A
|
| Abstract |
How developing axons in the corpus callosum (CC) achieve their homotopic projection to the contralateral cortex remains unclear. We found that axonal position within the CC plays a critical role in this projection. Labeling of nearby callosal axons in mice showed that callosal axons were segregated in an orderly fashion, with those from more medial cerebral cortex located more dorsally and subsequently projecting to more medial contralateral cortical regions. The normal axonal order within the CC was grossly disturbed when semaphorin3A/neuropilin-1 signaling was disrupted. However, the order in which axons were positioned within the CC still determined their contralateral projection, causing a severe disruption of the homotopic contralateral projection that persisted at postnatal day 30, when the normal developmental refinement of contralateral projections is completed in wild-type (WT) mice. Thus, the orderly positioning of axons within the CC is a primary determinant of how homotopic interhemispheric projections form in the contralateral cortex.
|
| 巻・号 |
110(29)
|
| ページ |
E2714-23
|
| 公開日 |
2013-7-16
|
| DOI |
10.1073/pnas.1310233110
|
| PII |
1310233110
|
| PMID |
23812756
|
| PMC |
PMC3718183
|
| MeSH |
Animals
Axons / physiology*
Bisbenzimidazole
Corpus Callosum / cytology
Corpus Callosum / embryology*
Electroporation
In Situ Hybridization
Mice
Mice, Inbred C57BL
Microscopy, Fluorescence
Neural Pathways / embryology*
Neuropilin-1 / metabolism*
Semaphorin-3A / metabolism*
Signal Transduction / physiology*
|
| IF |
9.412
|
| 引用数 |
42
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| 実験動物マウス |
RBRC01105
RBRC01106 |
