| RRC ID |
2717
|
| Author |
Sohda KY, Nagai K, Yamori T, Suzuki K, Tanaka A.
|
| Title |
YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. I. fermentation, isolation and biological activities.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
YM-216391, a novel cyclic peptide, was isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. It was purified by solvent extraction, silica gel and ODS flash column chromatographies, followed by preparative HPLC. YM-216391 dose-dependently inhibited the growth of human cervical cancer HeLa S3 cells with an IC50 value of 14nM. YM-216391 also showed potent cytotoxic activity against a human cancer cell line panel.
|
| Volume |
58(1)
|
| Pages |
27-31
|
| Published |
2005-1-1
|
| DOI |
10.1038/ja.2005.2
|
| PMID |
15813177
|
| MeSH |
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Fermentation*
HeLa Cells / drug effects
Humans
Molecular Structure
Oxazoles / chemistry
Oxazoles / isolation & purification*
Oxazoles / pharmacology
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Streptomyces
|
| IF |
2.668
|
| Times Cited |
8
|
| Resource |
| Pathogenic microorganisms |
JCM 4274? |
