論文 - 詳細
| RRC ID | 2765 |
|---|---|
| 著者 | Hida T, Takahashi E, Shikata K, Hirohashi T, Sawai T, Seiki T, Tanaka H, Kawai T, Ito O, Arai T, Yokoi A, Hirakawa T, Ogura H, Nagasu T, Miyamoto N, Kuromitsu J. |
| タイトル | Chronic intracerebroventricular administration of relaxin-3 increases body weight in rats. |
| ジャーナル | J Recept Signal Transduct Res |
| Abstract |
Bolus-administered intracerebroventricular (ICV) relaxin-3 has been reported to increase feeding. In this study, to examine the role of relaxin-3 signaling in energy homeostasis, we studied the effects of chronically administered ICV relaxin-3 on body weight gain and locomotor activity in rats. Two groups of animals received vehicle or relaxin-3 at 600 pmol/head/day, delivered with Alzet osmotic minipumps. In animals receiving relaxin-3, food consumption and weight gain were statistically significantly higher than those in the vehicle group during the 14-day infusion. During the light phase on days 2 and 7 and the dark phase on days 3 and 8, there was no difference in locomotor activity between the two groups. Plasma concentrations of leptin and insulin in rats chronically injected with relaxin-3 were significantly higher than in the vehicle-injected controls. These results indicate that relaxin-3 up-regulates food intake, leading to an increase of body weight and that relaxin-3 antagonists might be candidate antiobesity agents. |
| 巻・号 | 26(3) |
| ページ | 147-58 |
| 公開日 | 2006-1-1 |
| DOI | 10.1080/10799890600623373 |
| PII | W21K866071889832 |
| PMID | 16777712 |
| MeSH | Animals Body Weight / drug effects* Body Weight / physiology Eating / drug effects Eating / physiology Humans Injections, Intraventricular Insulin / blood Leptin / blood Male Motor Activity / drug effects Nerve Tissue Proteins / antagonists & inhibitors Nerve Tissue Proteins / physiology Obesity / drug therapy Obesity / etiology Obesity / physiopathology Rats Rats, Wistar Recombinant Proteins / administration & dosage Relaxin / administration & dosage Relaxin / analogs & derivatives* Relaxin / antagonists & inhibitors Relaxin / physiology Signal Transduction / drug effects |
| IF | 1.466 |
| 引用数 | 71 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ラット | |