| RRC ID |
27761
|
| 著者 |
Torigoe D, Ichii O, Dang R, Ohnaka T, Okano S, Sasaki N, Kon Y, Agui T.
|
| タイトル |
High-resolution linkage mapping of the rat hooded locus.
|
| ジャーナル |
J Vet Med Sci
|
| Abstract |
To identify a gene responsible for the hooded phenotype in the rat, high-resolution linkage mapping for the hooded locus was performed using IS (non-hooded) and LEA (hooded) rats. The map revealed that only Kit gene existed in the critical region, suggesting that the Kit is a strong candidate gene. However, mutation was not found in the coding region of the LEA rat Kit gene. Further, the expressions of Kit mRNA were not different in fetal neural tubes and both neonatal and adult skins between IS and LEA rats. Furthermore, Kit-positive cells, possibly melanocytes, were found in the non-pigmented hair follicles of hooded phenotype rats. Several hypotheses are conceivable to account for mechanisms in the appearance of hooded phenotype.
|
| 巻・号 |
73(5)
|
| ページ |
707-10
|
| 公開日 |
2011-5-1
|
| DOI |
10.1292/jvms.10-0529
|
| PII |
JST.JSTAGE/jvms/10-0529
|
| PMID |
21224527
|
| MeSH |
Animals
Chromosome Mapping*
Gene Expression Regulation
Genetic Linkage / genetics*
Hair Color / genetics*
Phenotype
Pigmentation / genetics*
Rats / genetics*
|
| IF |
1.049
|
| 引用数 |
2
|
|
WOS 分野
|
VETERINARY SCIENCES
|
| リソース情報 |
| ラット |
IS/Kyo(strainID=5)
LEA/Hok(strainID=70) |
