論文 - 詳細
| RRC ID | 28078 |
|---|---|
| 著者 | Ma X, Yang L, Yang Y, Li M, Li W, Xue L. |
| タイトル | dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila. |
| ジャーナル | Dev Biol |
| Abstract |
Loss of cell polarity cooperates with oncogenic Ras to induce JNK-dependent tumor growth and invasion. To identify additional genes that modulate tumor progression, we have performed a genetic screen in Drosophila and found that loss of dUev1a, the ortholog of mammalian Uev1, suppressed lgl(-/-)/Ras(V12) induced JNK-mediated tumor growth and invasion. Furthermore, loss of dUev1a suppressed TNF ortholog Eiger-induced JNK-mediated cell invasion and cell death. Finally, dUev1a cooperated with Bendless to activate JNK signaling through dTRAF2. Together, our data indicate that dUev1a encodes an essential component of the evolutionary conserved TNF-JNK signaling pathway that modulates tumor progression and cell death in metazoan. |
| 巻・号 | 380(2) |
| ページ | 211-21 |
| 公開日 | 2013-8-15 |
| DOI | 10.1016/j.ydbio.2013.05.013 |
| PII | S0012-1606(13)00258-3 |
| PMID | 23726905 |
| MeSH | Animals Cell Death Disease Progression Drosophila Drosophila Proteins / physiology* Early Growth Response Transcription Factors / physiology JNK Mitogen-Activated Protein Kinases / physiology* Matrix Metalloproteinase 1 / physiology Neoplasms / etiology* Neoplasms / pathology Signal Transduction / physiology* Transcription Factors / physiology* Tumor Necrosis Factor-alpha / physiology* Ubiquitin-Conjugating Enzymes / physiology* |
| IF | 2.896 |
| 引用数 | 35 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | |