論文 - 詳細
| RRC ID | 28096 |
|---|---|
| 著者 | Ibrahim DM, Biehs B, Kornberg TB, Klebes A. |
| タイトル | Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells identifies novel wing genes. |
| ジャーナル | G3 (Bethesda) |
| Abstract |
Signaling between cells in the anterior (A) and posterior (P) compartments directs Drosophila wing disc development and is dependent on expression of the homeodomain transcription factor Engrailed (En) in P cells. Downstream of en, posteriorly expressed Hedgehog (Hh) protein signals across the A/P border to establish a developmental organizer that directs pattern formation and growth throughout the wing primordium. Here we extend investigations of the processes downstream of en by using expression array analysis to compare A and P cells. A total of 102 candidate genes were identified that express differentially in the A and P compartments; four were characterized: Stubble (Sb) expression is restricted to A cells due to repression by en. CG15905, CG16884; CG10200/hase und igel (hui) are expressed in A cells downstream of Hh signaling; and RNA interference for hui, Stubble, and CG16884 revealed that each is essential to wing development. |
| 巻・号 | 3(8) |
| ページ | 1353-62 |
| 公開日 | 2013-8-7 |
| DOI | 10.1534/g3.113.006569 |
| PII | g3.113.006569 |
| PMID | 23749451 |
| PMC | PMC3737175 |
| MeSH | Animals Chromosome Mapping Drosophila / genetics* Drosophila / growth & development Drosophila Proteins / antagonists & inhibitors Drosophila Proteins / genetics* Drosophila Proteins / metabolism Gene Expression Regulation, Developmental Hedgehog Proteins / genetics Hedgehog Proteins / metabolism Homeodomain Proteins / genetics Homeodomain Proteins / metabolism Imaginal Discs / cytology* Imaginal Discs / metabolism Membrane Proteins / antagonists & inhibitors Membrane Proteins / genetics Membrane Proteins / metabolism Oligonucleotide Array Sequence Analysis RNA Interference Serine Endopeptidases / genetics Serine Endopeptidases / metabolism Signal Transduction / genetics Transcription Factors / genetics Transcription Factors / metabolism Wings, Animal / cytology* |
| IF | 2.781 |
| 引用数 | 11 |
| WOS 分野 | GENETICS & HEREDITY |
| リソース情報 | |
| ショウジョウバエ | 15905R-1 16884R-2 4316R-1 |