RRC ID 28169
Author Ishimaru K, Hirotsu N, Madoka Y, Murakami N, Hara N, Onodera H, Kashiwagi T, Ujiie K, Shimizu B, Onishi A, Miyagawa H, Katoh E.
Title Loss of function of the IAA-glucose hydrolase gene TGW6 enhances rice grain weight and increases yield.
Journal Nat. Genet.
Abstract Increases in the yield of rice, a staple crop for more than half of the global population, are imperative to support rapid population growth. Grain weight is a major determining factor of yield. Here, we report the cloning and functional analysis of THOUSAND-GRAIN WEIGHT 6 (TGW6), a gene from the Indian landrace rice Kasalath. TGW6 encodes a novel protein with indole-3-acetic acid (IAA)-glucose hydrolase activity. In sink organs, the Nipponbare tgw6 allele affects the timing of the transition from the syncytial to the cellular phase by controlling IAA supply and limiting cell number and grain length. Most notably, loss of function of the Kasalath allele enhances grain weight through pleiotropic effects on source organs and leads to significant yield increases. Our findings suggest that TGW6 may be useful for further improvements in yield characteristics in most cultivars.
Volume 45(6)
Pages 707-11
Published 2013-6
DOI 10.1038/ng.2612
PII ng.2612
PMID 23583977
MeSH Catalytic Domain Chromosome Mapping Cloning, Molecular Gene Expression Genetic Pleiotropy Haplotypes Hydrolases / chemistry Hydrolases / genetics* Hydrolases / metabolism Hydrolysis Indoleacetic Acids / chemistry Indoleacetic Acids / metabolism Models, Molecular Molecular Sequence Data Oryza / enzymology* Oryza / genetics Oryza / growth & development Plant Proteins / chemistry Plant Proteins / genetics* Plant Proteins / metabolism Seeds / enzymology* Seeds / genetics Seeds / growth & development Structural Homology, Protein
IF 27.959
Times Cited 86
WOS Category GENETICS & HEREDITY
Resource
Rice W0106 W0120 W1294 W1866 W1921 W2003 W0630 W1236 W1807 W1945 W2051 W2078 W2263 W1690