| RRC ID |
2823
|
| 著者 |
Imai K, Yamamoto M, Tanaka H, Hashimoto N, Miyakoshi M, Honmou S, Yoshie M, Tamakawa S, Yaginuma Y, Kasai S, Ogawa K.
|
| タイトル |
Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats.
|
| ジャーナル |
Oncol Rep
|
| Abstract |
In hepatocarcinogenesis-resistant DRH rats, preneoplastic hepatocytic lesions are smaller than those of usual rats during carcinogenesis. When preneoplastic hepatocytes from DRH and Donryu (original strain of DRH) were reciprocally transplanted into the livers of DRH and Donryu treated with 2-acetylaminofluorene (2-AAF) diet/two-thirds hepatectomy (PH), the Donryu cells formed small colonies within the DRH liver, whereas the DRH cells formed large colonies within the Donryu liver. The DRH liver showed less degree of oval cell proliferation after treatment with 2-AAF and PH, and DRH hepatocytes were more resistant to the growth-inhibitory effect of 2-AAF after PH. Furthermore, DRH hepatocytes were generally resistant to cytotoxicity of hepatotoxins. The tissue environment of the DRH liver, therefore, is less effective for selective growth of preneoplastic hepatocytes during the carcinogen treatment, which is probably a major cause of the hepatocarcinogenesis-resistance in DRH rats.
|
| 巻・号 |
17(1)
|
| ページ |
55-60
|
| 公開日 |
2007-1-1
|
| PMID |
17143478
|
| MeSH |
2-Acetylaminofluorene / administration & dosage
Animals
Carcinogens / administration & dosage
Cell Growth Processes / drug effects
Genetic Predisposition to Disease
Glutathione Transferase / biosynthesis
Hepatectomy
Hepatocytes / drug effects
Hepatocytes / enzymology
Hepatocytes / pathology*
Hepatocytes / transplantation
Liver Neoplasms, Experimental / chemically induced
Liver Neoplasms, Experimental / enzymology
Liver Neoplasms, Experimental / genetics
Liver Neoplasms, Experimental / pathology*
Male
Neoplasm Transplantation
Precancerous Conditions / chemically induced
Precancerous Conditions / enzymology
Precancerous Conditions / genetics
Precancerous Conditions / pathology*
Rats
Rats, Inbred Strains
|
| IF |
3.417
|
| 引用数 |
5
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ラット |
DON/Kyo(strainID=1)
DRH/Seac(strainID=111) |
